Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 13, Issue 10, Pages 646-658Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3432
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Funding
- Howard Hughes Medical Institute
- US National Institutes of Health (NIH) [GM19301, GM34921, DK54441]
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Protein kinases are dynamic molecular switches that have evolved to be only transiently activated. Kinase activity is embedded within a conserved kinase core, which is typically regulated by associated domains, linkers and interacting proteins. Moreover, protein kinases are often tethered to large macromolecular complexes to provide tighter spatiotemporal control. Thus, structural characterization of kinase domains alone is insufficient to explain protein kinase function and regulation in vivo. Recent progress in structural characterization of cyclic AMP-dependent protein kinase (PKA) exemplifies how our knowledge of kinase signalling has evolved by shifting the focus of structural studies from single kinase subunits to macromolecular complexes.
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