Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 13, Issue 6, Pages 397-404Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3352
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Funding
- Deutsche Forschungsgemeinschaft
- US National Institutes of Health (NIH) National Cancer Institute [R01, U01]
- Robert A. and Renee E. Belfer Foundation
- Ellison Foundation
- American Cancer Society
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Progressive DNA damage and mitochondrial decline are both considered to be prime instigators of natural ageing. Traditionally, these two pathways have been viewed largely in isolation. However, recent studies have revealed a molecular circuit that directly links DNA damage to compromised mitochondrial biogenesis and function via p53. This axis of ageing may account for both organ decline and disease development associated with advanced age and could illuminate a path for the development of relevant therapeutics.
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