Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 12, Issue 5, Pages 308-319Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3112
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Funding
- US Department of Defense Era of Hope [W81XWH-05-1-0330]
- US National Cancer Institute (NCI) [U54CA143836-01]
- US National Institutes of Health (NIH) [NCI R01 CA138818-01A1]
- NIH NCI Breast Spore [P50CA58207]
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All cells exist within the context of a three-dimensional microenvironment in which they are exposed to mechanical and physical cues. These cues can be disrupted through perturbations to mechanotransduction, from the nanoscale-level to the tissue-level, which compromises tensional homeostasis to promote pathologies such as cardiovascular disease and cancer. The mechanisms of such perturbations suggest that a complex interplay exists between the extracellular microenvironment and cellular function. Furthermore, sustained disruptions in tensional homeostasis can be caused by alterations in the extracellular matrix, allowing it to serve as a mechanically based memory-storage device that can perpetuate a disease or restore normal tissue behaviour.
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