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Turing's next steps: the mechanochemical basis of morphogenesis

Journal

NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 12, Issue 6, Pages 392-398

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NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3120

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Nearly 60 years ago, Alan Turing showed theoretically how two chemical species, termed morphogens, diffusing and reacting with each other can generate spatial patterns. Diffusion plays a crucial part in transporting chemical signals through space to establish the length scale of the pattern. When coupled to chemical reactions, mechanical processes - forces and flows generated by motor proteins - can also define length scales and provide a mechanochemical basis for morphogenesis.

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