Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 12, Issue 8, Pages 469-482Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3149
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Funding
- European Community [241548, 258068]
- European Science Foundation
- European Molecular Biology Organization (EMBO) Young Investigators Programme (YIP) fellowship
- Boehringer Ingelheim
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The mitosis-to-interphase transition involves dramatic cellular reorganization from a state that supports chromosome segregation to a state that complies with all functions of an interphase cell. This process, termed mitotic exit, depends on the removal of mitotic phosphorylations from a broad range of substrates. Mitotic exit regulation involves inactivation of mitotic kinases and activation of counteracting protein phosphatases. The key mitotic exit phosphatase in budding yeast, Cdc14, is now well understood. By contrast, in animal cells, it is now emerging that mitotic exit relies on distinct regulatory networks, including the protein phosphatases PP1 and PP2A.
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