Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 12, Issue 9, Pages 551-564Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3176
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Funding
- US National Institutes of Health [HL54737]
- Packard Foundation
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The vertebrate vasculature forms an extensive branched network of blood vessels that supplies tissues with nutrients and oxygen. During vascular development, coordinated control of endothelial cell behaviour at the levels of cell migration, proliferation, polarity, differentiation and cell-cell communication is critical for functional blood vessel morphogenesis. Recent data uncover elaborate transcriptional, post-transcriptional and post-translational mechanisms that fine-tune key signalling pathways (such as the vascular endothelial growth factor and Notch pathways) to control endothelial cell behaviour during blood vessel sprouting (angiogenesis). These emerging frameworks controlling angiogenesis provide unique insights into fundamental biological processes common to other systems, such as tissue branching morphogenesis, mechanotransduction and tubulogenesis.
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