Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 12, Issue 10, Pages 674-679Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3188
Keywords
-
Categories
Funding
- Dutch Cancer Society (KWF)
- Netherlands Organisation for Scientific Research (NWO)
Ask authors/readers for more resources
Autotaxin (ATX) is a secreted phosphodiesterase that produces the lipid mediator lysophosphatidic acid (LPA). LPA acts through specific guanine-nucleotide-binding protein (G protein)-coupled receptors to stimulate migration, proliferation, survival and other functions in many cell types. ATX is important in vivo for processes as diverse as vasculogenesis, lymphocyte trafficking and tumour progression. However, the inner workings of ATX have long been elusive, in terms of both its substrate specificity and how localized LPA signalling is achieved. Structural studies have shown how ATX recognizes its substrates and may interact with the cell surface to promote specificity in LPA signalling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available