Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 12, Issue 12, Pages 787-798Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3226
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Funding
- Medical Research Council, UK
- US National Institutes of Health [R01 GM086487]
- Camille and Henry Dreyfus Foundation
- Edward Mallinckrodt, Jr Foundation
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Membrane proteins are inserted into the endoplasmic reticulum (ER) by two highly conserved parallel pathways. The well-studied co-translational pathway uses signal recognition particle (SRP) and its receptor for targeting and the SEC61 translocon for membrane integration. A recently discovered post-translational pathway uses an entirely different set of factors involving transmembrane domain (TMD)-selective cytosolic chaperones and an accompanying receptor at the ER. Elucidation of the structural and mechanistic basis of this post-translational membrane protein insertion pathway highlights general principles shared between the two pathways and key distinctions unique to each.
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