Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 12, Issue 11, Pages 757-763Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3214
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Funding
- ALSAC/St. Jude
- US National Institutes of Health
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Caspase 8 can initiate apoptosis, but it also has non-apoptotic roles; for example, it is required for embryonic development and immune cell proliferation. Recent work has indicated that the requirement for caspase 8 in development and immune cell proliferation is defined by suppression of receptor-interacting protein kinase 3 (RIPK3), a kinase that triggers an alternative form of cell death called programmed necrosis. Interestingly, these recent findings can be reconciled with earlier work on the non-apoptotic roles of caspase 8.
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