Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 12, Issue 8, Pages 493-504Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3153
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Funding
- Simmons Scholars Program
- Allocation INSERM InCa/AVENIR [R08227AS]
- Kenan Foundation
- US National Institutes of Health [GM029860, HL080166]
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The 'invisible hand' is a term originally coined by Adam Smith in The Theory of Moral Sentiments to describe the forces of self-interest, competition and supply and demand that regulate the resources in society. This metaphor continues to be used by economists to describe the self-regulating nature of a market economy. The same metaphor can be used to describe the RHO-specific guanine nucleotide dissociation inhibitor (RHOGDI) family, which operates in the background, as an invisible hand, using similar forces to regulate the RHO GTPase cycle.
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