Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 12, Issue 3, Pages 198-202Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3060
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Funding
- European Research Council
- Wallonia Region
- Fondation contre le Cancer
- EMBO
- US National Institutes of Health
- US National Institutes of Aging [AG029760-01]
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In contrast to postmitotic or short-lived somatic cells, tissue-specific stem cells must persist and function throughout life to ensure tissue homeostasis and repair. The enormous functional demands and longevity of stem cells raises the possibility that stem cells might be uniquely equipped to maintain genomic integrity in ways different than somatic cells. Indeed, evidence suggests that stem cell compartments possess unique properties that combine to either limit or, in some instances, accelerate DNA damage accrual.
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