Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 12, Issue 9, Pages 594-604Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3169
Keywords
-
Categories
Funding
- Max-Planck-Gesellschaft
- Swiss National Science Foundation
- Swiss SystemsX.ch initiative
- ERC
- [LipidX-2008/011]
Ask authors/readers for more resources
Morphogens are secreted signalling molecules that control the patterning and growth of developing organs. How morphogens regulate patterning is fairly well understood; however, how they control growth is less clear. Four principal models have been proposed to explain how the morphogenetic protein Decapentaplegic ( DPP) controls the growth of the wing imaginal disc in the fly. Recent studies in this model system have provided a wealth of experimental data on growth and DPP gradient properties, as well as on the interactions of DPP with other signalling pathways. These findings have allowed a more precise formulation and evaluation of morphogenetic growth models. The insights into growth control by the DPP gradient will also be useful for understanding other morphogenetic growth systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available