Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 12, Issue 11, Pages 749-756Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3212
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Funding
- US National Institutes of Health [R01 GM90317, GM057464]
- Cell Migration Consortium [U54 GM64346]
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Cellular signal transduction occurs in complex and redundant interaction networks, which are best understood by simultaneously monitoring the activation dynamics of multiple components. Recent advances in biosensor technology have made it possible to visualize and quantify the activation of multiple network nodes in the same living cell. The precision and scope of this approach has been greatly extended by novel computational approaches ( referred to as computational multiplexing) that can reveal relationships between network nodes imaged in separate cells.
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