Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 12, Issue 8, Pages 535-541Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3150
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A little over 1 year ago, we lost a bright scientist and a dear colleague who, in his younger years, proposed the 'heretical' idea that lysosomes could selectively degrade cytosolic proteins. That scientist was J. Fred Dice, and his lifetime's discovery was the degradative pathway that we now know as chaperone-mediated autophagy.
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