Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 11, Issue 12, Pages 849-860Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3010
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Funding
- Austrian Academy of Science
- Austrian Science Fund (FWF)
- The European Research Council (ERC)
- European Union
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The ability of cells to divide asymmetrically is essential for generating diverse cell types during development. The past 10 years have seen tremendous progress in our understanding of this important biological process. We have learned that localized phosphorylation events are responsible for the asymmetric segregation of cell fate determinants in mitosis and that centrosomes and microtubules play important parts in this process. The relevance of asymmetric cell division for stem cell biology has added a new dimension to the field, and exciting connections between asymmetric cell division and tumorigenesis have begun to emerge.
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