Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 11, Issue 5, Pages 366-378Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2889
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Funding
- Wellcome Trust [081172/Z/06/Z]
- National Institute of Health Research
- Peter Hans Hofschneider Foundation for Experimental Biomedicine
- German Research Foundation
- Max Planck Society
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The shuttling of leukocytes between the bloodstream and interstitial tissues involves different locomotion strategies that are governed by locally presented soluble and cell-bound signals. Recent studies have furthered our understanding of the rapidly advancing field of leukocyte migration, particularly regarding cellular and subcellular events at the level of the venular wall. Furthermore, emerging cellular models are now addressing the transition from an adherent mode to a non-adherent state, incorporating mechanisms that support an efficient migratory profile of leukocytes in the interstitial tissue beyond the venular wall.
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