Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 11, Issue 6, Pages 453-458Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2905
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Funding
- Medical Research Council [G0802579] Funding Source: Medline
- Medical Research Council [G0802579] Funding Source: researchfish
- MRC [G0802579] Funding Source: UKRI
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Current descriptions of eukaryotic chemotaxis and cell movement focus on how extracellular signals (chemoattractants) cause new pseudopods to form. This 'signal-centred' approach is widely accepted but is derived mostly from special cases, particularly steep chemoattractant gradients. I propose a 'pseudopod-centred' explanation, whereby most pseudopods form themselves, without needing exogenous signals, and chemoattractants only bias internal pseudopod dynamics. This reinterpretation of recent data suggests that future research should focus on pseudopod mechanics, not signal processing.
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