Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 11, Issue 8, Pages 556-566Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2937
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Funding
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- Intramural AIDS Targeted Antiretroviral Program
- American Heart Association
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The endosomal sorting complexes required for transport (ESCRTs) catalyse one of the most unusual membrane remodelling events in cell biology. ESCRT-I and ESCRT-II direct membrane budding away from the cytosol by stabilizing bud necks without coating the buds and without being consumed in the buds. ESCRT-III cleaves the bud necks from their cytosolic faces. ESCRT-III-mediated membrane neck cleavage is crucial for many processes, including the biogenesis of multivesicular bodies, viral budding, cytokinesis and, probably, autophagy. Recent studies of ultrastructures induced by ESCRT-III overexpression in cells and the in vitro reconstitution of the budding and scission reactions have led to breakthroughs in understanding these remarkable membrane reactions.
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