Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 11, Issue 10, Pages 688-699Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2977
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Funding
- EU [LSHB-CT2007-037, 740]
- DFG [Schwerpunktprogramm 1175]
- BMBF [0313,827, 03FO1212]
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Ten years ago, we wrote a Review on lipid rafts and signalling in the launch issue of Nature Reviews Molecular Cell Biology. At the time, this field was suffering from ambiguous methodology and imprecise nomenclature. Now, new techniques are deepening our insight into the dynamics of membrane organization. Here, we discuss how the field has matured and present an evolving model in which membranes are occupied by fluctuating nanoscale assemblies of sphingolipids, cholesterol and proteins that can be stabilized into platforms that are important in signalling, viral infection and membrane trafficking.
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