Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 11, Issue 3, Pages 171-181Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2848
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Funding
- George E. Hewitt Foundation for Medical Research
- National Institutes of Health [RO1 GM06525, RO1 AG025837]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM087476, R01GM069525] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG025837] Funding Source: NIH RePORTER
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The natural ends of linear chromosomes require unique genetic and structural adaptations to facilitate the protection of genetic material. This is achieved by the sequestration of the telomeric sequence into a protective nucleoprotein cap that masks the ends from constitutive exposure to the DNA damage response machinery. When telomeres are unmasked, genome instability arises. Balancing capping requirements with telomere replication and the enzymatic processing steps that are obligatory for telomere function is a complex problem. Telomeric proteins and their interacting factors create an environment at chromosome ends that inhibits DNA repair; however, the repair machinery is essential for proper telomere function.
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