Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 11, Issue 5, Pages 342-352Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2883
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Funding
- Director, Office of Science, Office of Basic Energy Sciences, Chemical Sciences, Geosciences and Biosciences Division of the U.S. Department of Energy [DE-AC02-05CH11231]
- National Science Foundation [MCB-0448614]
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The coordinated organization of cell membrane receptors into diverse micrometre-scale spatial patterns is emerging as an important theme of intercellular signalling, as exemplified by immunological synapses. Key characteristics of these patterns are that they transcend direct protein-protein interactions, emerge transiently and modulate signal transduction. Such cooperativity over multiple length scales presents new and intriguing challenges for the study and ultimate understanding of cellular signalling. As a result, new experimental strategies have emerged to manipulate the spatial organization of molecules inside living cells. The resulting spatial mutations yield insights into the interweaving of the spatial, mechanical and chemical aspects of intercellular signalling.
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