Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 11, Issue 12, Pages 823-833Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3007
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Funding
- UK Biotechnology and Biological Sciences Research Council
- The Wellcome Trust, UK
- US National Institutes of Health National Institute of General Medical Sciences (NIGMS)
- National Science Foundation (ADVANCE) USA
- Biotechnology and Biological Sciences Research Council [BB/H012982/1] Funding Source: researchfish
- BBSRC [BB/H012982/1] Funding Source: UKRI
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Prions are unusual proteinaceous infectious agents that are typically associated with a class of fatal degenerative diseases of the mammalian brain. However, the discovery of fungal prions, which are not associated with disease, suggests that we must now consider the effect of these factors on basic cellular physiology in a different light. Fungal prions are epigenetic determinants that can alter a range of cellular processes, including metabolism and gene expression pathways, and these changes can lead to a range of prion-associated phenotypes. The mechanistic similarities between prion propagation in mammals and fungi suggest that prions are not a biological anomaly but instead could be a newly appreciated and perhaps ubiquitous regulatory mechanism.
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