Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 10, Issue 8, Pages 526-537Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2727
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Funding
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Medical Research Council [G0800784, G0300723, G0700098, G120/824] Funding Source: Medline
- MRC [G120/824, G0300723, G0800784, G0700098] Funding Source: UKRI
- Medical Research Council [G0300723, G0800784, G0300723B, G120/824, G0700098, G0800784B] Funding Source: researchfish
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Cells of the early mammalian embryo, including pluripotent embryonic stem (ES) cells and primordial germ cells (PGCs), are epigenetically dynamic and heterogeneous. During early development, this heterogeneity of epigenetic states is associated with stochastic expression of lineage-determining transcription factors that establish an intimate crosstalk with epigenetic modifiers. Lineage-specific epigenetic modification of crucial transcription factor loci (for example, methylation of the Elf5 promoter) leads to the restriction of transcriptional circuits and the fixation of lineage fate. The intersection of major epigenetic reprogramming and programming events in the early embryo creates plasticity followed by commitment to the principal cell lineages of the early conceptus.
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