Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 10, Issue 2, Pages 126-139Publisher
NATURE RESEARCH
DOI: 10.1038/nrm2632
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Funding
- Creative Research Initiatives Program
- BK21 Research Funds from the Ministry of Education
- Science and Technology of Korea, New Energy and Industrial Technology Development Organization ( NEDO)
- Core Research for Evolutionary Science and Technology ( CREST) from the Japan Science and Technology Agency ( JST)
- National Research Foundation of Korea [과06A1204, 2007-0054849] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Small RNAs of 20-30 nucleotides can target both chromatin and transcripts, and thereby keep both the genome and the transcriptome under extensive surveillance. Recent progress in high-throughput sequencing has uncovered an astounding landscape of small RNAs in eukaryotic cells. Various small RNAs of distinctive characteristics have been found and can be classified into three classes based on their biogenesis mechanism and the type of Argonaute protein that they are associated with: microRNAs (miRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs) and Piwi-interacting RNAs (piRNAs). This Review summarizes our current knowledge of how these intriguing molecules are generated in animal cells.
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