Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 10, Issue 9, Pages 609-622Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2748
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Funding
- National Institutes of Health (NIH) [CA089151, CA112219, DA014204, DA000439, DA012864]
- NATIONAL CANCER INSTITUTE [R01CA089151, R01CA112219] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [K02DA000439, R01DA012864, Z01DA000439, R01DA014204] Funding Source: NIH RePORTER
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Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct processes. Although our present understanding is incomplete and there are still great controversies, it is now recognized that these processes are intimately and bidirectionally linked in animal cells. Indeed, many recent examples illustrate how endocytosis regulates receptor signalling (including signalling from receptor tyrosine kinases and G protein-coupled receptors) and, conversely, how signalling regulates the endocytic pathway. The mechanistic and functional principles that underlie the relationship between signalling and endocytosis in cell biology are becoming increasingly evident across many systems.
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