Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 10, Issue 4, Pages 276-U57Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2654
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Funding
- National Center of Competence in Research
- Swiss National Science Foundation
- Kanton of Zurich
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The canonical Wnt pathway has gathered much attention in recent years owing to its fundamental contribution to metazoan development, tissue homeostasis and human malignancies. Wnt target gene transcription is regulated by nuclear beta-catenin, and genetic assays have revealed various collaborating protein cofactors. Their daunting number and diverse nature, however, make it difficult to arrange an orderly picture of the nuclear Wnt transduction events. Yet, these findings emphasize that beta-catenin-mediated transcription affects chromatin. How does beta-catenin cope with chromatin regulation to turn on Wnt target genes?
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