Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 10, Issue 6, Pages 398-409Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2690
Keywords
-
Categories
Funding
- Canadian Institute of Health Research
- National Cancer Institute of Canada/Canadian Cancer Society
- National Health and Medical Research Council of Australia
- Australian Research Council
Ask authors/readers for more resources
The ubiquitylation of proteins is carried out by E1, E2 and E3 (ubiquitin ligase) enzymes, and targets them for degradation or for other cellular fates. The HECT enzymes, including Nedd4 family members, are a major group of E3 enzymes that dictate the specificity of ubiquitylation. In addition to ubiquitylating proteins for degradation by the 26S proteasome, HECT E3 enzymes regulate the trafficking of many receptors, channels, transporters and viral proteins. The physiological functions of the yeast HECT E3 ligase Rsp5 are the best known, but the functions of HECT E3 enyzmes in metazoans are now becoming clearer from in vivo studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available