Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 10, Issue 3, Pages 165-177Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrm2639
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Funding
- Deutsche Forschungsgemeinschaft, Finish Cancer Organizations
- Academy of Finland, Helsinki University Central Hospital
- Korea Science and Engineering Foundation (KOSEF)
- Louis Jeantet Foundation
- Novo Nordisk Foundation
- Aventis Foundation
- German Israel Foundation and the European Union
- National Institutes of Health
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Angiogenesis, the growth of blood vessels, is a fundamental biological process that controls embryonic development and is also involved in numerous life-threatening human diseases. Much work in the field of angiogenesis research has centred on the vascular endothelial growth factor (VEGF)-VEGF receptor system. The Tie receptors and their angiopoietin (Ang) ligands have been identified as the second vascular tissue-specific receptor Tyr kinase system. Ang-Tie signalling is essential during embryonic vessel assembly and maturation, and functions as a key regulator of adult vascular homeostasis. The structural characteristics and the spatio-temporal regulation of the expression of receptors and ligands provide unique insights into the functions of this vascular signalling system.
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