Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 10, Issue 11, Pages 765-777Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2782
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Funding
- NIGMS NIH HHS [R01 GM070862-05, R01 GM070862] Funding Source: Medline
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Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments. Much progress has been made in understanding the mechanics and functions of the kinesin motors that play important parts in cell division, cell motility, intracellular trafficking and ciliary function. How kinesins are regulated in cells to ensure the temporal and spatial fidelity of their microtubule-based activities is less well understood. Recent work has revealed molecular mechanisms that control kinesin autoinhibition and subsequent activation, binding to cargos and microtubule tracks, and localization at specific sites of action.
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