Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 10, Issue 5, Pages 353-359Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2680
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Funding
- Comunidad de Madrid [SAF2008-02635, INSINET-0159/2006]
- Red Tematica de Investigacion Cooperativa en Enfermedades Cardiovasculares [RD06/0014-0030]
- FIPSE (Fundacion para la Investigacion y Prevencion del SIDA en Espana) [36289/02]
- Contrato-Investigador FIS (Ministerio de Ciencia e Innovacion, Spain) [PI070356, SAF2008-01339-E]
- Spanish Ministry of Science and Innovation
- Pro-CNIC Foundation
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Renewed interest in cell shape has been prompted by a recent flood of evidence that indicates that cell polarity is essential for the biology of motile cells. The uropod, a protrusion at the rear of amoeboid motile cells such as leukocytes, exemplifies the importance of morphology in cell motility. Remodelling of cell shape by uropod-interfering agents disturbs cell migration. But even though the mechanisms by which uropods regulate cell migration are beginning to emerge, their functional significance remains enigmatic.
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