Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 10, Issue 1, Pages 34-43Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2592
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Funding
- National Institutes of Health (NIBIB, NHLBI and NIGMS)
- Army Research Office Multidisciplinary University Research Initiative
- Ruth L. Kirschstein National Research Service Award
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL073305] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [P30AR050950] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000262] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM074048] Funding Source: NIH RePORTER
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Mechanotransduction research has focused historically on how externally applied forces can affect cell signalling and function. A growing body of evidence suggests that contractile forces that are generated internally by the actomyosin cytoskeleton are also important in regulating cell behaviour, and suggest a broader role for mechanotransduction in biology. Although the molecular basis for these cellular forces in mechanotransduction is being pursued in cell culture, researchers are also beginning to appreciate their contribution to in vivo developmental processes. Here, we examine the role for mechanical forces and contractility in regulating cell and tissue structure and function during development.
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