Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 10, Issue 3, Pages 207-U67Publisher
NATURE RESEARCH
DOI: 10.1038/nrm2636
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Funding
- Human Frontiers in Science Program Organization (HFSPO)
- Belgian Fund for Scientific Research (FRS/FNRS), Wallonia Region
- Schlumberger Foundation
- European Research Council
- National Institutes of Health
- Starr Foundation
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR050452] Funding Source: NIH RePORTER
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The skin epidermis and its array of appendages undergo ongoing renewal by a process called homeostasis. Stem cells in the epidermis have a crucial role in maintaining tissue homeostasis by providing new cells to replace those that are constantly lost during tissue turnover or following injury. Different resident skin stem cell pools contribute to the maintenance and repair of the various epidermal tissues of the skin, including interfollicular epidermis, hair follicles and sebaceous glands. Interestingly, the basic mechanisms and signalling pathways that orchestrate epithelial morphogenesis in the skin are reused during adult life to regulate skin homeostasis.
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