Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 10, Issue 3, Pages 228-U85Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2633
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Funding
- Office of Biological and Environmental Research of the Department of Energy [DE-AC03-76SF00098]
- Distinguished Fellow Award
- National Cancer Institute [CA64786, CA57621, CA122086, CA128660]
- Department of Defense
- NATIONAL CANCER INSTITUTE [R21CA128660, R01CA122086, R01CA064786, R01CA057621, R37CA064786] Funding Source: NIH RePORTER
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The maintenance of organ homeostasis and the control of an appropriate response to environmental alterations require the intimate coordination of cellular functions and tissue organization. An important component of this coordination could be provided by proteins that can have distinct but linked functions on both sides of the plasma membrane. We present a model that proposes that unconventional secretion provides a mechanism through which single proteins can integrate complex tissue functions.
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