Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 10, Issue 12, Pages 843-853Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2799
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Funding
- Cancer Research UK
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Since it has become clear that adhesion receptors are trafficked through the endosomal pathway and that this can influence their function, much effort has been invested in obtaining detailed descriptions of the molecular machinery responsible for internalizing and recycling integrins. New findings indicate that integrin trafficking dictates the nature of Rho GTPase signalling during cytokinesis and cell migration. Furthermore, integrins can exert control over the trafficking of other receptors in a way that drives cancer cell invasion and tumour angiogenesis.
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