Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 10, Issue 10, Pages 672-681Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2766
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Funding
- NIDDK NIH HHS [R01 DK061845-04, U01 DK063481-03S1, R01 DK061845, P01 DK055820-050001, U01 DK063481, R01 DK042989, R37 DK042989, R01 DK042989-09, R01 DK054493-04, U01 DK063481-03, R37 DK042989-20, P01 DK055820] Funding Source: Medline
- NIGMS NIH HHS [RC1 GM091176, R01 GM078465-04, R01 GM078465, P50 GM071558, P50 GM071558-01A20007, P50 GM071558-030007, P50 GM071558-020007, RC1 GM091176-01] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK042989, R37DK042989, U01DK063481, R01DK054493, P01DK055820, R01DK061845] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P50GM071558, R01GM078465, RC1GM091176] Funding Source: NIH RePORTER
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Stem cell differentiation and the maintenance of self-renewal are intrinsically complex processes requiring the coordinated dynamic expression of hundreds of genes and proteins in precise response to external signalling cues. Numerous recent reports have used both experimental and computational techniques to dissect this complexity. These reports suggest that the control of cell fate has both deterministic and stochastic elements: complex underlying regulatory networks define stable molecular 'attractor' states towards which individual cells are drawn over time, whereas stochastic fluctuations in gene and protein expression levels drive transitions between coexisting attractors, ensuring robustness at the population level.
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