Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 9, Issue 4, Pages 309-322Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2369
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Microtubule plus-end tracking proteins (+ TIPs) are a diverse group of evolutionarily conserved cellular factors that accumulate at the ends of growing microtubules. They form dynamic networks through the interaction of a limited set of protein modules, repeat sequences and linear motifs that bind to each other with moderate affinities. + TIPs regulate different aspects of cell architecture by controlling microtubule dynamics, microtubule interactions with cellular structures and signalling factors, and the forces that are exerted on microtubule networks.
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