Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 9, Issue 4, Pages 273-284Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2378
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Funding
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
- Telethon [GGP06166, GGP04235] Funding Source: Medline
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The composition and identity of cell organelles are dictated by the flux of lipids and proteins that they receive and lose through cytosolic exchange and membrane trafficking. The trans-Golgi network (TGN) is a major sorting centre for cell lipids and proteins at the crossroads of the endocytic and exocytic pathways; it has a complex dynamic structure composed of a network of tubular membranes that generate pleiomorphic carriers targeted to different destinations. Live-cell imaging combined with three-dimensional tomography has recently provided the temporal and topographical framework that allows the assembly of the numerous molecular machineries so far implicated in sorting and trafficking at the TGN.
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