Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 9, Issue 4, Pages 297-308Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2351
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Funding
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
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The repair of DNA lesions that occur endogenously or in response to diverse genotoxic stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways that regulate specific DNA-repair mechanisms in the different phases of the cell cycle. Checkpoint-arrested cells resume cell-cycle progression once damage has been repaired, whereas cells with unrepairable DNA lesions undergo permanent cell-cycle arrest or apoptosis. Recent studies have provided insights into the mechanisms that contribute to DNA repair in specific cell-cycle phases and have highlighted the mechanisms that ensure cell-cycle progression or arrest in normal and cancerous cells.
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