Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 9, Issue 12, Pages 1004-1010Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2529
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Funding
- National Institutes of Health
- American Cancer Society
- Ellison Medical Foundation
- Ligue Nationale Contre le Cancer
- Agence Nationale de Recherche
- Institut National du Cancer
- Canceropole Ile-de-France
- European Union
- Fondation pour la Recherche Medicale
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Dying cells often display a large-scale accumulation of autophagosomes and hence adopt a morphology called autophagic cell death. In many cases, it is agreed that this autophagic cell death is cell death with autophagy rather than cell death by autophagy. Here, we evaluate the accumulating body of literature that argues that cell death occurs by autophagy. We also list the caveats that must be considered when deciding whether or not autophagy is an important effector mechanism of cell death.
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