Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 9, Issue 2, Pages 177-182Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2309
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Funding
- Biotechnology and Biological Sciences Research Council [BB/C510291/1] Funding Source: Medline
- Medical Research Council [G0600233] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/C510291/1] Funding Source: researchfish
- Medical Research Council [G0300662B, G0600233] Funding Source: researchfish
- MRC [G0600233] Funding Source: UKRI
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Of the three structural maintenance of chromosome (SMC) complexes, two directly regulate chromosome dynamics. The third, Smc5/6, functions mainly in homologous recombination and in completing DNA replication. The literature suggests that Smc5/6 coordinates DNA repair, in part through post-translational modification of uncharacterized target proteins that can dictate their subcellular localization, and that Smc5/6 also functions to establish DNA-damage-dependent cohesion. A nucleolar-specific Smc5/6 function has been proposed because Smc5/6 yeast mutants display penetrant phenotypes of ribosomal DNA ( rDNA) instability. rDNA repeats are replicated unidirectionally. Here, we propose that unidirectional replication, combined with global Smc5/6 functions, can explain the apparent rDNA specificity.
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