Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 9, Issue 7, Pages 543-556Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2417
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Funding
- MRC [MC_U105178795] Funding Source: UKRI
- Medical Research Council [MC_U105178795] Funding Source: researchfish
- Medical Research Council [MC_U105178795] Funding Source: Medline
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Membrane fusion can occur between cells, between different intracellular compartments, between intracellular compartments and the plasma membrane and between lipid-bound structures such as viral particles and cellular membranes. In order for membranes to fuse they must first be brought together. The more highly curved a membrane is, the more fusogenic it becomes. We discuss how proteins, including SNAREs, synaptotagmins and viral fusion proteins, might mediate close membrane apposition and induction of membrane curvature to drive diverse fusion processes. We also highlight common principles that can be derived from the analysis of the role of these proteins.
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