Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 9, Issue 5, Pages 367-377Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2391
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Funding
- NIDDK NIH HHS [DK030898, P30 DK032520-25, R01 DK030648-25, R37 DK030898-22, DK030648, R37 DK030898, P30 DK032520, R01 DK030648, R01 DK030898, DK32520] Funding Source: Medline
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Acquired resistance to the action of insulin to stimulate glucose transport in skeletal muscle is associated with obesity and promotes the development of type 2 diabetes. In skeletal muscle, insulin resistance can result from high levels of circulating fatty acids that disrupt insulin signalling pathways. However, the severity of insulin resistance varies greatly among obese people. Here we postulate that this variability might reflect differences in levels of lipid-droplet proteins that promote the sequestration of fatty acids within adipocytes in the form of triglycerides, thereby lowering exposure of skeletal muscle to the inhibitory effects of fatty acids.
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