Journal
NATURE REVIEWS MICROBIOLOGY
Volume 12, Issue 4, Pages 239-251Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrmicro3236
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Funding
- Vessa Notchev Fellowship from Sigma Delta Epsilon-Graduate Women in Science (SDE-GWIS)
- US National Institutes of Health [AI081704]
- National Science Foundation [1021120]
- Investigator in the Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1021120] Funding Source: National Science Foundation
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Sexual reproduction is a pervasive attribute of eukaryotic species and is now recognized to occur in many clinically important human fungal pathogens. These fungi use sexual or parasexual strategies for various purposes that can have an impact on pathogenesis, such as the formation of drug-resistant isolates, the generation of strains with increased virulence or the modulation of interactions with host cells. In this Review, we examine the mechanisms regulating fungal sex and the consequences of these programmes for human disease.
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