Journal
NATURE REVIEWS MICROBIOLOGY
Volume 12, Issue 12, Pages 809-821Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3365
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- Deutsche Forschungsgemeinschaft
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Life on earth evolved in the absence of oxygen with inorganic gases as potential sources of carbon and energy. Among the alternative mechanisms for carbon dioxide (CO2) fixation in the living world, only the reduction of CO2 by the Wood-Ljungdahl pathway, which is used by acetogenic bacteria, complies with the two requirements to sustain life: conservation of energy and production of biomass. However, how energy is conserved in acetogenic bacteria has been an enigma since their discovery. In this Review, we discuss the latest progress on the biochemistry and genetics of the energy metabolism of model acetogens, elucidating how these bacteria couple CO2 fixation to energy conservation.
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