Journal
NATURE REVIEWS MICROBIOLOGY
Volume 13, Issue 2, Pages 71-82Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3393
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Funding
- Washington State University funds
- Public Health Service (PHS) [AI112649]
- PHS [AIAI050553, AI097107, AI090387]
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The unfolded protein response (UPR) is a cytoprotective response that is aimed at restoring cellular homeostasis following physiological stress exerted on the endoplasmic reticulum (ER), which also invokes innate immune signalling in response to invading microorganisms. Although it has been known for some time that the UPR is modulated by various viruses, recent evidence indicates that it also has multiple roles during bacterial infections. In this Review, we describe how bacteria interact with the ER, including how bacteria induce the UPR, how subversion of the UPR promotes bacterial proliferation and how the UPR contributes to innate immune responses against invading bacteria.
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