Journal
NATURE REVIEWS MICROBIOLOGY
Volume 12, Issue 1, Pages 35-48Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3155
Keywords
-
Categories
Funding
- Deutsche Forschungsgemeinschaft [WI3285/2-1]
- EMBO young investigator grant
Ask authors/readers for more resources
The ribosome is one of the main antibiotic targets in the bacterial cell. Crystal structures of naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal particles have provided unparalleled insight into their mechanisms of action, and they are also facilitating the design of more effective antibiotics for targeting multidrug-resistant bacteria. In this Review, I discuss the recent structural insights into the mechanism of action of ribosome-targeting antibiotics and the molecular mechanisms of bacterial resistance, in addition to the approaches that are being pursued for the production of improved drugs that inhibit bacterial protein synthesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available