Journal
NATURE REVIEWS MICROBIOLOGY
Volume 12, Issue 10, Pages 715-722Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrmicro3312
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Funding
- Deutsche Forschungsgemeinschaft
- Volkswagenstiftung
- German Federal Ministry of Education and Research (BMBF)
- European Community
- European Research Council
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Almost all human proteins are subject to proteolytic degradation, which produces a broad range of peptides that have highly specific and sometimes unexpected functions. Peptide libraries that have been generated from human bodily fluids or tissues are a rich but mostly unexplored source of bioactive compounds that could be used to develop antimicrobial and immunomodulatory therapeutic agents. In this Innovation article, we describe the discovery, optimization and application of endogenous bioactive peptides from human-derived peptide libraries, with a particular focus on the isolation of endogenous inhibitors and promoters of HIV-1 infection.
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