Journal
NATURE REVIEWS MICROBIOLOGY
Volume 11, Issue 7, Pages 467-481Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3047
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Funding
- NIAID NIH HHS [AI064184, R56 AI076322, R01 AI064184, R01 AI076322, AI76322] Funding Source: Medline
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Gram-negative bacteria decorate their outermost surface structure, lipopolysaccharide, with elaborate chemical moieties, which effectively disguises them from immune surveillance and protects them from the onslaught of host defences. Many of these changes occur on the lipid A moiety of lipopolysaccharide, a component that is crucial for host recognition of Gram-negative infection. In this Review, we describe the regulatory mechanisms controlling lipid A modification and discuss the impact of modifications on pathogenesis, bacterial physiology and bacterial interactions with the host immune system.
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