Journal
NATURE REVIEWS MICROBIOLOGY
Volume 11, Issue 5, Pages 349-355Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3007
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Funding
- Science Foundation Ireland
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Data obtained with advanced imaging techniques, chromosome conformation capture methods, bioinformatics and molecular genetics, together with insights from polymer physics and mechanobiology, are helping to refine our understanding of the spatiotemporal organization of the bacterial nucleoid and its gene expression programmes. Here, l discuss the proposal that, in addition to DNA topology and nucleoid-associated proteins, gene regulation is an important organizing principle of nucleoid architecture.
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