Journal
NATURE REVIEWS MICROBIOLOGY
Volume 11, Issue 5, Pages 316-326Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3009
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Funding
- US National Institutes of Health (NIH) [AI055472, AI079022]
- National Research Service Award fellowship from NIH
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Several bacterial species have evolved specialized secretion systems to deliver bacterial effector proteins into eukaryotic cells. These effectors have the capacity to modulate host cell pathways in order to promote bacterial survival and replication. The spatial and temporal context in which the effectors exert their biochemical activities is crucial for their function. To fully understand effector function in the context of infection, we need to understand the mechanisms that lead to the precise subcellular localization of effectors following their delivery into host cells. Recent studies have shown that bacterial effectors exploit host cell machinery to accurately target their biochemical activities within the host cell.
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